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Journal Of Tuberculosis Research And Treatment Pdf

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Table of Contents

Coronavirus Guidelines. Visit free Relief Central. Prime PubMed is provided free to individuals by: Unbound Medicine. Tuberculosis research and treatment[TA]. Ion Transport Modulators as Antimycobacterial Agents. There is an urgent need for better and safer therapeutic interventions for tuberculosis TB. We assessed the effects of FDA-approved ion transport modulators, namely, ambroxol HCl, amiloride HCl, diazoxide, digoxin, furosemide, hydrochlorothiazide HCTZ , metformin, omeprazole, pantoprazole, phenytoin, verapamil, and drug X and Y on the growth of free and intracellular Mycobacterium bovis BCG.

Free and intracellular M. To assess the effects of the drugs on bactericidal activity of rifampicin, free and intracellular M. For extracellular bacteria, higher bacteria clearance rates were observed in cultures exposed to rifampicin in combination with amiloride HCl, diazoxide, digoxin, furosemide, HCTZ, metformin, pantoprazole, phenytoin, drug X, or drug Y than those exposed to rifampicin alone, indicating that rifampicin had a synergistic effect with these test drugs.

Rifampicin was also synergistic with ambroxol HCl, diazoxide, digoxin, furosemide, HCTZ, omeprazole, pantoprazole, phenytoin, verapamil, and drug X against intracellular M.

The antimycobacterial properties exhibited by the ion transport modulators in this study make them viable candidates as adjuncts to the current anti-TB regimens. Delay in the diagnosis and treatment of tuberculosis exacerbates the disease and clinical outcomes. It further enhances transmission of the infection in the society as well as increased the severity of the illness and raised rate of mortality.

Oxidative stress is a common feature of tuberculosis TB , and persons with reduced antioxidants are at more risk of TB. TB patients with relatively severe oxidative stress had also more advanced disease as measured by the Karnofsky performance index. Since adverse effects from anti-TB drugs are also mediated by free radicals, TB patients are prone to side effects, such as hearing loss.

However, before embarking on such trials, considerations of NAC's overall impact on TB treatment are crucial. This paper discusses NAC's effect on mycobacterial clearance, hearing loss, drug-induced liver injury, and its interaction with anti-TB drugs. Based on the evidence accrued to date, NAC appears to have various beneficial effects on TB treatment. However, despite the favorable interaction between NAC and first-line anti-TB drugs, the interaction between the antioxidant and some of the second-line anti-TB drugs needs further investigations.

The aim of this study was to assess community members' knowledge and awareness levels, attitudes, and practices of Drug Resistant Tuberculosis. A quantitative descriptive cross sectional study was carried out in the Eastern Cape Province of South Africa. The sample size consisted of four hundred respondents aged 18 years and above on their last birthday who were purposively and conveniently selected from Port Elizabeth area in the Nelson Mandela Municipality.

Data were collected using close-ended questions, which were administered by the researcher and two research assistants to the selected respondents. Data were analysed using descriptive statistics. The results of this study show poor knowledge and awareness levels, unfavourable attitudes, but good prevention practices of Drug Resistant Tuberculosis among Port Elizabeth community members.

The study also revealed low literacy levels, inadequate information, misconceptions and erroneous beliefs about causes, transmission, prevention, treatment, and management of Drug Resistant Tuberculosis among the respondents. This study also highlighted the use and existence of dual healthcare system traditional spiritual and western. The study found that the main source of Drug Resistant TB information was radio and television among the majority of research respondents.

It is recommended that in future health education interventions and awareness campaigns need to be intensified in the area so that misconceptions and erroneous beliefs that exist in society can be addressed. It is also recommended that training programs that are culturally sensitive should be developed and delivered taking into account different languages and literacy levels that exist in society. Such education interventions should be facilitated in collaboration with people living with Drug Resistant Tuberculosis.

A multidisciplinary approach should be fostered and collaborations with spiritual healers and various congregational leaders, traditional health practitioners, community leaders, and government leaders in the health sector should be promoted in order to deal with Drug Resistant Tuberculosis.

It is also recommended that a similar study be conducted using a qualitative research approach in urban and rural areas of the Eastern Cape. Lastly, assessment of knowledge, attitudes, and practices of spiritual and traditional healers with regard to Drug Resistant Tuberculosis should be conducted as they can influence health-seeking behaviour.

ICM health staff implemented symptom screening in villages and suspected cases were referred to the closest rural health unit RHU for TB testing. ACF was carried out in Mindanao and the Visayas, across 16 different provinces. A multilevel regression model was constructed to explore the effect of factors on the likelihood of getting tested.

A total of individuals were screened; From those referred, 7. The finding that the presence of cough is associated with higher rate of testing suggests that individuals in these settings might not know or believe that the lack of cough does not equate to lack of TB infection. While technologies and screening algorithms give us the ability to refine the 'supply' side of the TB screening, addressing the knowledge gap should improve 'demand'. Globally, transferring TB patients to another health unit for treatment continuation is common trend while posing challenges for proper treatment outcomes monitoring.

National guidelines indicated the importance of incorporating the treatment outcomes of those cases by the transferring unit when performing annual cohort analysis. However, in most instances, this is not taken into account. This study was conducted to determine the characteristics and treatment outcomes of 'transfer out' TB cases during the time period between and at four Hospitals of Tigray: Ethiopia. Initial data was extracted from TB treatment logbooks of transferring units using standardize checklist that were followed by a visit to each of the receiving units.

The generated data were entered and analyzed using SPSS v. Descriptive statistics were computed. P-value less than 0. A total of TB patients were transferred out during the specified time period whereas From these, more than three-quarters, However, none of the transferring unit received and traced status of the cases.

Therefore, regular monitoring is needed to improve the existing communication gap. Other similar studies conducted elsewhere, however, did not report gout as an adverse effect. It is unknown why a higher incidence of gout is being reported in Eritrea compared to similar studies from other countries.

The objective of this study is therefore to explore risk factors for the increased risk of incident gout among MDR-TB patients in Eritrea. Controls matched by age, sex, and cumulative drug exposure time were selected from the same study population ratio. In conclusion, MDR-TB patients with diabetes mellitus, tachycardia, alopecia, and gastrointestinal upset and on prolonged use of propranolol tablet had increased risk of incident gout.

It disproportionally affects those living in the different regions of countries and within the region. The aim of this study was to examine spatial variation of mortality and the risk factor of death on multidrug-resistant tuberculosis patients treated in different MDR-TB hospitals of Amhara region. The data for this study was used from multidrug-resistant tuberculosis patients' record charts and analyzed using STATA software.

The result of this study shows that 61 This study revealed that there was no heterogeneity for death in patients treated in different hospitals. Older patients, therapeutic delay, alcohol use, any clinical complication previously not treated, HIV coinfection, and presence of any chronic disease were the risk factors that influenced the death of multidrug-resistant tuberculosis patients.

Tuberculosis

Explore the latest in tuberculosis, including recent advances in screening, prevention, diagnosis, treatment, and global control. A woman in her 50s presented with an edematous, massively enlarged right auricle; histopathologic evaluation revealed noncaseating granulomatous dermatitis. What is your diagnosis? This pooled cohort study evaluates the safety of newer biological agents for the treatment of tuberculosis infection and activation in patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis. This Arts and Medicine feature describes the integration of local dance traditions into pulmonary rehabilitation programs for COPD and tuberculosis patients in low- and middle-income countries. This cohort study examines the joint association of silica dust exposure and cigarette smoking with mortality among a cohort of adults who worked in mines or pottery factories in China between and , with a total follow-up period of 44 years.

Coronavirus Guidelines. Visit free Relief Central. Prime PubMed is provided free to individuals by: Unbound Medicine. Tuberculosis research and treatment[TA]. Ion Transport Modulators as Antimycobacterial Agents. There is an urgent need for better and safer therapeutic interventions for tuberculosis TB. We assessed the effects of FDA-approved ion transport modulators, namely, ambroxol HCl, amiloride HCl, diazoxide, digoxin, furosemide, hydrochlorothiazide HCTZ , metformin, omeprazole, pantoprazole, phenytoin, verapamil, and drug X and Y on the growth of free and intracellular Mycobacterium bovis BCG.


Tuberculosis Research and Treatment - Table of contents. +Journal Menu Predictors of Adverse TB Treatment Outcome among TB/HIV Patients Compared with Non-HIV Author guidelines Editorial board Databases and indexing.


Tuberculosis

Once production of your article has started, you can track the status of your article via Track Your Accepted Article. Indian Journal of Tuberculosis IJTB is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc.

Journal of Tuberculosis Research

Нестерпимая боль пронзила плечо, сдавила грудь и, подобно миллиону осколков, вонзилась в мозг. Клушар увидел яркую вспышку света… и черную бездну. Человек ослабил нажим, еще раз взглянул на прикрепленную к спинке кровати табличку с именем больного и беззвучно выскользнул из палаты. Оказавшись на улице, человек в очках в тонкой металлической оправе достал крошечный прибор, закрепленный на брючном ремне, - квадратную коробочку размером с кредитную карту.

За мгновение до того, как они сомкнулись, Сьюзан, потеряв равновесие, упала на пол за дверью. Коммандер, пытаясь приоткрыть дверь, прижал лицо вплотную к узенькой щелке. - Господи Боже мой, Сьюзан, с тобой все в порядке. Она встала на ноги и расправила платье. - Все обошлось.

 Ох! - Она не могла скрыть разочарование.  - Здравствуйте, шеф. - Думала, кое-кто помоложе? - засмеялся Стратмор. - Да нет, сэр, - попыталась она сгладить неловкость.  - Не в этом дело… - Да в этом.

Tuberculosis

4 Comments

Avent C. 19.03.2021 at 23:57

Tuberculosis Research and Treatment publishes original research articles, review articles, and clinical studies related to all aspects of tuberculosis, from the immunological basis of disease to translational and clinical research.

Eustache F. 22.03.2021 at 17:07

Once production of your article has started, you can track the status of your article via Track Your Accepted Article.

Weipropimcher 25.03.2021 at 11:25

Once production of your article has started, you can track the status of your article via Track Your Accepted Article.

Uta B. 26.03.2021 at 14:17

Journal profile. Tuberculosis Research and Treatment publishes original research articles, review articles, and clinical studies related to all aspects of tuberculosis.

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